CKDdb-logoCKDdb - Molecule ID A368F

geneARHGEF3
nameRho guanine nucleotide exchange factor 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG3_HUMANQ9NR81ENSP0000029631550650Hs.476402612115

Functions and classifications

GOC:cytosol, F:Rho guanyl-nucleotide exchange factor activity, P:apoptotic signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:Rho protein signal transduction, P:intracellular signal transduction, P:regulation of Rho GTPase activity, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction, C:intracellular
UniProtAlternative splicing, Complete proteome, Cytoplasm, Guanine-nucleotide releasing factor, Polymorphism, Reference proteome
PADBMOD: modulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.09< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)3.220.004063539LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium