CKDdb-logoCKDdb - Molecule ID A3659

geneACSL6, ACS2, FACL6
nameLong-chain-fatty-acid--CoA ligase 6
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL6_HUMANQ9UKU0ENSG0000016439823305Hs.14945604443

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:membrane, C:mitochondrial outer membrane, C:nucleus, C:peroxisomal membrane, C:plasma membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, F:protein homodimerization activity, P:cellular response to insulin stimulus, P:fatty acid transport, P:long-chain fatty-acyl-CoA biosynthetic process, P:neuroblast proliferation, P:neuron development, P:phospholipid biosynthetic process, P:positive regulation of neuron projection development, P:positive regulation of plasma membrane long-chain fatty acid transport, P:positive regulation of triglyceride biosynthetic process, P:response to gravity, P:response to hypoxia, P:response to nutrient, P:response to steroid hormone, P:triglyceride biosynthetic process, C:mitochondrion, P:triglyceride metabolic process, F:catalytic activity, F:ligase activity, C:integral to membrane, P:long-chain fatty acid metabolic process
UniProtAlternative splicing, ATP-binding, Chromosomal rearrangement, Complete proteome, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Reference proteome, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 2.080.01cDNA microarray  19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.30.00603RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.320.000553RNA microarray  19698090
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease) 3.150.0397049RNA microarray  23935909
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.332.41E-03RNA microarray  26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.180.014215RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium