CKDdb-logoCKDdb - Molecule ID A3598

geneALDH2, ALDM
nameAldehyde dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALDH2_HUMANP05091ENSG00000111275217Hs.604551100650, 610251

Functions and classifications

GOC:mitochondrial matrix, F:aldehyde dehydrogenase (NAD) activity, F:aldehyde dehydrogenase [NAD(P)+] activity, F:electron carrier activity, P:carbohydrate metabolic process, P:ethanol catabolic process, P:ethanol oxidation, P:neurotransmitter biosynthetic process, P:xenobiotic metabolic process, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, F:oxidoreductase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.260.00000114RNA microarray19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)4.18< 0.05LC-MS/MS19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.543.59E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.224.90E-03Nano RP-LC, MALDI-TOF22061828
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.326.30E-03Nano RP-LC, MALDI-TOF22061828
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy)0.52< 0.05MALDI-TOF/TOF24434790
Exp25279147Homo sapiens12kidneybiopsy sectionGlomerulonephritis (IgA nephropathy)0.47< 0.05MALDI TOF/TOF25279147

Compile date 08-10-2018© iMODE-CKD consortium