CKDdb-logoCKDdb - Molecule ID A3597

geneALDH1A3, ALDH6
nameAldehyde dehydrogenase 6
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL1A3_HUMANP47895ENSG00000184254220Hs.459538600463, 615113

Functions and classifications

GOC:cytoplasm, F:aldehyde dehydrogenase (NAD) activity, F:aldehyde dehydrogenase [NAD(P)+] activity, F:NAD+ binding, F:protein homodimerization activity, F:thyroid hormone binding, P:embryonic eye morphogenesis, P:face development, P:inner ear morphogenesis, P:locomotory behavior, P:neuromuscular process controlling balance, P:nucleus accumbens development, P:olfactory pit development, P:optic cup morphogenesis involved in camera-type eye development, P:positive regulation of apoptotic process, P:retinal metabolic process, P:retinoic acid biosynthetic process, P:retinoic acid metabolic process, P:retinol metabolic process, P:righting reflex, F:oxidoreductase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, P:kidney development, P:pituitary gland development, P:response to drug
UniProtAcetylation, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Microphthalmia, NAD, Oxidoreductase, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.00789RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.14< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.255.08E-25NGS, RNA-seq.22266139
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.318.92E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium