CKDdb-logoCKDdb - Molecule ID A3596

geneALDH1A2, RALDH2, RALDH2-T
nameRetinal dehydrogenase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL1A2_HUMANO94788ENSG000001289188854Hs.643455603687

Functions and classifications

GOC:cytoplasm, C:cytosol, C:nucleus, C:perinuclear region of cytoplasm, F:3-chloroallyl aldehyde dehydrogenase activity, F:retinal binding, F:retinal dehydrogenase activity, P:9-cis-retinoic acid biosynthetic process, P:anterior/posterior pattern specification, P:blood vessel development, P:cardiac muscle tissue development, P:cellular response to retinoic acid, P:determination of bilateral symmetry, P:embryonic camera-type eye development, P:embryonic digestive tract development, P:embryonic forelimb morphogenesis, P:face development, P:heart morphogenesis, P:hindbrain development, P:kidney development, P:liver development, P:lung development, P:midgut development, P:morphogenesis of embryonic epithelium, P:negative regulation of cell proliferation, P:neural crest cell development, P:neural tube development, P:neuron differentiation, P:pancreas development, P:pituitary gland development, P:positive regulation of apoptotic process, P:positive regulation of cell proliferation, P:positive regulation of gene expression, P:proximal/distal pattern formation, P:regulation of endothelial cell proliferation, P:response to cytokine, P:response to estradiol, P:response to vitamin A, P:retinal metabolic process, P:retinoic acid metabolic process, P:retinoic acid receptor signaling pathway, P:retinol metabolic process, P:ureter maturation, P:vitamin A metabolic process, C:cytoplasm, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, P:oxidation-reduction process, P:response to cytokine stimulus, P:response to estradiol stimulus
UniProtAlternative splicing, Complete proteome, Cytoplasm, NAD, Oxidoreductase, Polymorphism, Reference proteome, Phosphoprotein
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)6.4< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)3.5< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00239RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.490.0388RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.320.001cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.34< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.26< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.23< 0.05RNA-seq23757392
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium