CKDdb-logoCKDdb - Molecule ID A3586

geneACLY
nameATP-citrate synthase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACLY_HUMANP53396ENSG0000013147347Hs.387567108728

Functions and classifications

GOC:citrate lyase complex, C:cytosol, C:mitochondrion, C:nucleus, C:plasma membrane, F:ATP binding, F:ATP citrate synthase activity, F:cofactor binding, F:metal ion binding, F:succinate-CoA ligase (ADP-forming) activity, P:ATP catabolic process, P:cellular carbohydrate metabolic process, P:citrate metabolic process, P:coenzyme A metabolic process, P:energy reserve metabolic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:positive regulation of cellular metabolic process, P:triglyceride biosynthetic process, C:cytoplasm, F:nucleotide binding
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Isopeptide bond, Lipid biosynthesis, Lipid metabolism, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Transferase, Ubl conjugation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease) 0.460.0283682RNA microarray  19698090
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease) 2.010.014272RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 2.410.000585RNA microarray  19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model) 1.52< 0.05LC-MS/MS  20940332
Exp23809614aHomo sapiens83bloodwholeChronic_Renal_Insufficiency (End-stage renal failure) 0.255.37E-13RNA microarray  23809614
Exp23809614bHomo sapiens32bloodwholeChronic_Renal_Insufficiency (End-stage renal failure) 0.154.00E-10RNA microarray  23809614
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model) 0.690.035996062LC-MS/MS  24316357

Compile date 08-30-2016© iMODE-CKD consortium