CKDdb-logoCKDdb - Molecule ID A3585

geneAldh
nameRetinal dehydrogenase 1
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL1A1_RATP51647ENSRNOG0000001761924188Rn.6132100640

Functions and classifications

GOC:cytoplasm, C:nucleus, F:3-chloroallyl aldehyde dehydrogenase activity, F:aldehyde dehydrogenase (NAD) activity, F:benzaldehyde dehydrogenase (NAD+) activity, F:identical protein binding, F:retinal dehydrogenase activity, P:9-cis-retinoic acid biosynthetic process, P:9-cis-retinoic acid metabolic process, P:estrous cycle phase, P:kidney development, P:liver development, P:midgut development, P:optic cup morphogenesis involved in camera-type eye development, P:positive regulation of apoptotic process, P:protein homotetramerization, P:response to drug, P:response to estradiol, P:response to ethanol, P:response to organic cyclic compound, P:response to oxidative stress, P:response to retinoic acid, P:retinoic acid biosynthetic process, P:retinol metabolic process, P:response to estradiol stimulus
UniProtAcetylation, Complete proteome, Cytoplasm, Direct protein sequencing, NAD, Oxidoreductase, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.69< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.11< 0.05cDNA microarray17003339
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy)down< 0.05MALDI17081055
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.70.05RNA microarray17579666
Exp19099603aMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.050.01cDNA microarray19099603
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.610.01cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)11.570.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)5.90.01cDNA microarray19099603
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)2.230.004MALDI-TOF/TOF21544065
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.380.00487RNA microarray23291264
Exp25449168Rattus norvegicus pancreasbeta-cells (INS-1 cell line)Diabetes (pancreatic beta-cell function)3.3 LC-MS/MS25449168
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.445.41E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium