CKDdb-logoCKDdb - Molecule ID A3583

geneACACB, ACC2, ACCB
nameAcetyl-CoA carboxylase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACACB_HUMANO00763ENSG0000007655532Hs.234898601557

Functions and classifications

GOC:cytosol, C:endomembrane system, C:membrane, C:mitochondrion, F:acetyl-CoA carboxylase activity, F:ATP binding, F:biotin binding, F:biotin carboxylase activity, F:metal ion binding, P:acetyl-CoA metabolic process, P:biotin metabolic process, P:carnitine shuttle, P:cellular lipid metabolic process, P:energy reserve metabolic process, P:fatty acid biosynthetic process, P:malonyl-CoA biosynthetic process, P:positive regulation of cellular metabolic process, P:protein homotetramerization, P:response to drug, P:response to organic cyclic compound, C:cytoplasm, P:regulation of fatty acid oxidation, P:small molecule metabolic process
UniProt3D-structure, Allosteric enzyme, Alternative splicing, ATP-binding, Biotin, Complete proteome, Fatty acid biosynthesis, Fatty acid metabolism, Ligase, Lipid biosynthesis, Lipid metabolism, Manganese, Membrane, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.290.0000312RNA microarray  19698090
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 6.360.013MALDI-TOF/TOF  21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.25< 0.05RNA microarray  21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.31< 0.05RNA microarray  21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.35< 0.05RNA microarray  21752957

Compile date 08-30-2016© iMODE-CKD consortium