CKDdb-logoCKDdb - Molecule ID A3582

geneAcaca, Acac, Gm738
nameAcetyl-CoA carboxylase 1
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACACA_MOUSEQ5SWU9ENSMUSG00000020532107476Mm.31374200350, 613933

Functions and classifications

GOC:cytosol, C:mitochondrion, F:acetyl-CoA carboxylase activity, F:ATP binding, F:biotin carboxylase activity, F:metal ion binding, F:protein binding, P:acetyl-CoA metabolic process, P:fatty acid biosynthetic process, P:lipid homeostasis, P:lipid metabolic process, P:malonyl-CoA biosynthetic process, P:multicellular organismal protein metabolic process, P:protein homotetramerization, P:tissue homeostasis, C:mitochondrion, F:acetyl-CoA carboxylase activity, F:ATP binding, F:biotin carboxylase activity, P:lipid homeostasis, P:lipid metabolic process, P:multicellular organismal protein metabolic process, P:tissue homeostasis, C:mitochondrion, F:acetyl-CoA carboxylase activity, P:lipid homeostasis, P:lipid metabolic process, P:multicellular organismal protein metabolic process, P:tissue homeostasis, C:mitochondrion, F:acetyl-CoA carboxylase activity, F:ATP binding, P:fatty acid biosynthetic process, P:lipid homeostasis, P:lipid metabolic process, P:multicellular organismal protein metabolic process, P:tissue homeostasis, C:mitochondrion, F:acetyl-CoA carboxylase activity, P:lipid homeostasis, P:lipid metabolic process, P:multicellular organismal protein metabolic process, P:tissue homeostasis, C:mitochondrion, F:acetyl-CoA carboxylase activity, P:lipid homeostasis, P:lipid metabolic process, P:multicellular organismal protein metabolic process, P:tissue homeostasis
UniProtAcetylation, Allosteric enzyme, Alternative promoter usage, ATP-binding, Biotin, Complete proteome, Cytoplasm, Direct protein sequencing, Fatty acid biosynthesis, Fatty acid metabolism, Ligase, Lipid biosynthesis, Lipid metabolism, Manganese, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Phosphoprotein, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 4.24< 0.05LC-MS/MS  19845401
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes) 0.87< 0.001RP-nano-LC-ESI-MS/MS  20348205
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 3.860.013MALDI-TOF/TOF  21544065
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.490.000526RNA microarray  24569379
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.50.00052RNA microarray  24569379

Compile date 08-30-2016© iMODE-CKD consortium