CKDdb-logoCKDdb - Molecule ID A354F

geneAplf
nameAprataxin and PNK-like factor
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APLF_MOUSEQ9D842ENSMUSG0000003005172103Mm.31770611035

Functions and classifications

GOC:cytosol, C:nucleus, F:3'-5' exonuclease activity, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:endodeoxyribonuclease activity, F:metal ion binding, F:nucleotide binding, P:cellular response to DNA damage stimulus, P:DNA catabolic process, endonucleolytic, P:double-strand break repair, P:nucleic acid phosphodiester bond hydrolysis, P:regulation of isotype switching, P:single strand break repair
UniProtADP-ribosylation, Alternative splicing, Coiled coil, Complete proteome, Cytoplasm, DNA damage, DNA repair, Lyase, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Repeat, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.440.00000832RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.277.31E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.414.35E-05RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.150.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium