CKDdb-logoCKDdb - Molecule ID A353F

geneAPH-1b, APH1B, PSFL
nameGamma-secretase subunit APH-1B
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APH1B_HUMANQ8WW43ENSG0000013861383464Hs.511703607630

Functions and classifications

GOC:integral component of membrane, C:plasma membrane, C:transport vesicle, F:peptidase activity, P:apoptotic signaling pathway, P:membrane protein intracellular domain proteolysis, P:neurotrophin TRK receptor signaling pathway, P:Notch receptor processing, P:Notch signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of catalytic activity, P:protein processing, C:integral to membrane, P:apoptotic process, P:nerve growth factor receptor signaling pathway
UniProtAlternative splicing, Complete proteome, Membrane, Notch signaling pathway, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.411.88E-06RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium