CKDdb-logoCKDdb - Molecule ID A3502

geneAAK1
nameAP2 associated kinase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
AAK1_HUMANQ2M2I8ENSG0000011597722848Hs.468878

Functions and classifications

GOC:cell leading edge, C:clathrin-coated vesicle, C:coated pit, C:extrinsic component of plasma membrane, C:terminal bouton, F:AP-2 adaptor complex binding, F:ATP binding, F:Notch binding, F:protein serine/threonine kinase activity, P:endocytosis, P:positive regulation of Notch signaling pathway, P:protein autophosphorylation, P:protein stabilization, P:regulation of clathrin-mediated endocytosis, P:regulation of protein localization, C:clathrin complex, C:extrinsic to plasma membrane, C:terminal button
UniProtAcetylation, Alternative splicing, ATP-binding, Cell membrane, Coated pit, Complete proteome, Endocytosis, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease) 2.680.0151576RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.310.00000154RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.350.00141RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.390.00111RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.430.0316RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.440.00000557RNA microarray  19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 3.28< 0.05LC-MS/MS  19845401
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease) 0.420.0289323RNA microarray  23935909

Compile date 08-30-2016© iMODE-CKD consortium