CKDdb-logoCKDdb - Molecule ID A3494

geneAGRN, AGRIN
nameAgrin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AGRIN_HUMANO00468ENSG00000188157375790Hs.273330103320, 254300

Functions and classifications

GOC:basal lamina, C:cell junction, C:cell surface, C:extracellular space, C:Golgi lumen, C:integral component of membrane, C:lysosomal lumen, C:plasma membrane, C:synapse, F:acetylcholine receptor regulator activity, F:calcium ion binding, F:chondroitin sulfate binding, F:dystroglycan binding, F:heparan sulfate proteoglycan binding, F:laminin binding, F:sialic acid binding, F:structural constituent of cytoskeleton, P:axon guidance, P:carbohydrate metabolic process, P:chondroitin sulfate metabolic process, P:clustering of voltage-gated sodium channels, P:extracellular matrix organization, P:G-protein coupled acetylcholine receptor signaling pathway, P:glycosaminoglycan biosynthetic process, P:glycosaminoglycan catabolic process, P:neuromuscular junction development, P:neurotransmitter receptor metabolic process, P:phototransduction, visible light, P:plasma membrane organization, P:positive regulation of filopodium assembly, P:positive regulation of neuron apoptotic process, P:positive regulation of Rho GTPase activity, P:positive regulation of synaptic growth at neuromuscular junction, P:positive regulation of transcription from RNA polymerase II promoter, P:receptor clustering, P:regulation of receptor activity, P:retinoid metabolic process, P:synapse organization, C:basal lamina, P:positive regulation of protein geranylgeranylation, P:positive regulation of protein phosphorylation, P:regulation of Rac GTPase activity, P:synapse assembly, P:synapse organization
UniProtAlternative splicing, Calcium, Cell junction, Cell membrane, Complete proteome, Congenital myasthenic syndrome, Developmental protein, Differentiation, Disease mutation, Disulfide bond, EGF-like domain, Extracellular matrix, Glycoprotein, Heparan sulfate, Laminin EGF-like domain, Membrane, Polymorphism, Proteoglycan, Reference proteome, Repeat, Secreted, Signal, Synapse, Transmembrane, Transmembrane helix
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.190.000322RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.000402RNA microarray19698090
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.770.049MALDI-TOF/TOF21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.29< 0.05RNA microarray21752957
Exp22007191Rattus norvegicus20kidneyglomeruliDiabetes (Diabetic Nephropathy)0.620.042LC-ESI-MS/MS22007191
Exp23536133aHomo sapiens8urinewholeDiabetes (type 2 diabetes)23.30.029LC-MS/MS23536133
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0.5 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.5 1DE, MALDI24096133
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)3.28 +/- 0.38< 0.001RNA microarray24189015
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)3.33 +/- 0.47< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)3.45 +/- 0.93< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)3.60 +/- 0.43< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)1.80 +/- 1.45< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)2.71 +/- 1.01< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)2.01 +/- 0.65< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)2.43 +/- 0.83< 0.001RNA microarray24189015
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)00.009105888LC-MS/MS24316357
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)0.65<0.05nano-LC-MS/MS25957429

Compile date 08-10-2018© iMODE-CKD consortium