CKDdb-logoCKDdb - Molecule ID A347J

geneAgtr1, Agtr1a, At1a
nameType-1A angiotensin II receptor
speciesRattus norvegicus

Molecule reference


Functions and classifications

GOC:basolateral plasma membrane, C:cytoplasmic vesicle, C:dendrite, C:endomembrane system, C:Golgi apparatus, C:integral component of membrane, C:membrane, C:organelle outer membrane, C:plasma membrane, C:recycling endosome, C:vesicle lumen, C:vesicle membrane, F:angiotensin type I receptor activity, F:angiotensin type II receptor activity, F:D1 dopamine receptor binding, F:G-protein alpha-subunit binding, F:peptide hormone binding, F:protein binding, F:protein kinase binding, F:protein self-association, P:activation of Janus kinase activity, P:aging, P:blood vessel development, P:brain renin-angiotensin system, P:cellular response to dexamethasone stimulus, P:dopamine biosynthetic process, P:drinking behavior, P:G-protein coupled receptor signaling pathway, P:heart development, P:inflammatory response, P:kidney development, P:negative regulation of smooth muscle cell apoptotic process, P:phospholipase C-activating angiotensin-activated signaling pathway, P:phospholipase C-activating G-protein coupled receptor signaling pathway, P:positive regulation of blood pressure, P:positive regulation of branching involved in ureteric bud morphogenesis, P:positive regulation of cell proliferation, P:positive regulation of cytokine secretion, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of receptor recycling, P:positive regulation of superoxide anion generation, P:regulation of blood pressure, P:regulation of pH, P:regulation of renal output by angiotensin, P:regulation of vasoconstriction, P:renin secretion into blood stream, P:renin-angiotensin regulation of aldosterone production, P:response to estrogen, P:vasoconstriction, C:integral to membrane, P:elevation of cytosolic calcium ion concentration, P:response to estrogen stimulus
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix

Studies, tissues and diseases

Study IDSpeciesTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23291264bRattus norvegicuskidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.180.000602RNA microarray23291264

Compile date 08-10-2018© iMODE-CKD consortium