CKDdb-logoCKDdb - Molecule ID A3470

geneATP12A, ATP1AL1
namePotassium-transporting ATPase alpha chain 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AT12A_HUMANP54707ENSG00000075673479Hs.147111182360

Functions and classifications

GOC:basolateral plasma membrane, C:hydrogen:potassium-exchanging ATPase complex, F:ATP binding, F:hydrogen:potassium-exchanging ATPase activity, F:metal ion binding, P:ATP biosynthetic process, P:ATP catabolic process, P:potassium ion homeostasis, P:potassium ion transmembrane transport, P:regulation of pH, C:integral component of membrane, F:cation-transporting ATPase activity, F:monovalent inorganic cation transmembrane transporter activity, P:ion transmembrane transport, C:apical plasma membrane, P:response to metal ion, P:response to organic cyclic compound, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, P:ATP biosynthetic process
UniProtAlternative splicing, ATP-binding, Complete proteome, Hydrogen ion transport, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Potassium, Potassium transport, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.250.000249RNA microarray19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)3.51< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium