CKDdb-logoCKDdb - Molecule ID A337J

geneCALCA, CALC1
nameCalcitonin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CALCA_HUMANP06881ENSG00000110680796Hs.37058114130

Functions and classifications

GOC:cytoplasm, C:extracellular space, F:protein complex binding, F:receptor binding, P:activation of adenylate cyclase activity, P:cell-cell signaling, P:endothelial cell migration, P:endothelial cell proliferation, P:G-protein coupled receptor internalization, P:leukocyte cell-cell adhesion, P:negative regulation of blood pressure, P:negative regulation of bone resorption, P:negative regulation of calcium ion transport into cytosol, P:negative regulation of osteoclast differentiation, P:neurological system process involved in regulation of systemic arterial blood pressure, P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, P:positive regulation of interleukin-1 alpha production, P:positive regulation of interleukin-8 production, P:positive regulation of macrophage differentiation, P:positive regulation of vasodilation, P:protein phosphorylation, P:regulation of blood pressure, P:vasculature development, C:cytoplasm, C:neuronal cell body, C:nucleus, C:terminal bouton, P:activation of protein kinase activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:aging, P:detection of temperature stimulus involved in sensory perception of pain, P:embryo implantation, P:feeding behavior, P:inflammatory response, P:monocyte chemotaxis, P:negative regulation of neurological system process, P:negative regulation of ossification, P:negative regulation of smooth muscle contraction, P:negative regulation of transcription, DNA-templated, P:neuropeptide signaling pathway, P:positive regulation of adenylate cyclase activity, P:positive regulation of ossification, P:regulation of heart rate, P:regulation of inflammatory response, P:response to heat, P:response to pain, P:vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure, P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, P:vasodilation, C:terminal button, P:negative regulation of transcription, DNA-dependent
UniProt3D-structure, Alternative splicing, Amidation, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Hormone, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.240.000783RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.250.000559RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.024RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.00216RNA microarray19698090
Exp20706631Mus musculus6kidneyglomerular capillary endothelial cellDiabetes (diabetic nephropathy)5.31< 0.05RNA microarray20706631
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)2.880.0357028RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium