CKDdb-logoCKDdb - Molecule ID A3267

geneBcl6, Bcl-6
nameB-cell lymphoma 6 protein homolog
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BCL6_MOUSEP41183ENSMUSG0000002250812053Mm.347398109565

Functions and classifications

GOC:nucleus, C:replication fork, F:chromatin binding, F:chromatin DNA binding, F:DNA binding, F:metal ion binding, F:protein binding, F:sequence-specific DNA binding, F:sequence-specific DNA binding transcription factor activity, P:actin cytoskeleton organization, P:B cell differentiation, P:cell morphogenesis, P:cellular response to DNA damage stimulus, P:erythrocyte development, P:germinal center formation, P:inflammatory response, P:negative regulation of apoptotic process, P:negative regulation of cell differentiation, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of cell-matrix adhesion, P:negative regulation of isotype switching to IgE isotypes, P:negative regulation of mast cell cytokine production, P:negative regulation of Rho protein signal transduction, P:negative regulation of T-helper 2 cell differentiation, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of type 2 immune response, P:positive regulation of apoptotic process, P:positive regulation of B cell proliferation, P:positive regulation of cellular component movement, P:protein import into nucleus, translocation, P:protein localization, P:regulation of cell proliferation, P:regulation of inflammatory response, P:regulation of memory T cell differentiation, P:regulation of Rho GTPase activity, P:Rho protein signal transduction, P:spermatogenesis, P:transcription, DNA-templated, P:type 2 immune response, F:zinc ion binding, P:response to DNA damage stimulus, P:transcription, DNA-dependent
UniProtAcetylation, Activator, Complete proteome, DNA-binding, Immunity, Inflammatory response, Metal-binding, Nucleus, Phosphoprotein, Reference proteome, Repeat, Repressor, Transcription, Transcription regulation, Ubl conjugation, Zinc, Zinc-finger
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.44< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.54< 0.05cDNA microarray17003339
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)2.640.0248RNA microarray20847290

Compile date 08-10-2018© iMODE-CKD consortium