CKDdb-logoCKDdb - Molecule ID A306F

geneANKRD1, CARP, HA1A2
nameAnkyrin repeat domain-containing protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANKR1_HUMANQ15327ENSG0000014867727063Hs.448589106700, 609599

Functions and classifications

GOC:cytosol, C:I band, C:nucleoplasm, C:transcription factor complex, F:DNA binding, F:RNA polymerase II transcription coactivator activity, F:transcription corepressor activity, P:cardiac muscle tissue morphogenesis, P:cellular lipid metabolic process, P:cellular response to drug, P:cellular response to hypoxia, P:cellular response to interleukin-1, P:cellular response to lipopolysaccharide, P:cellular response to mechanical stimulus, P:cellular response to organic cyclic compound, P:cellular response to transforming growth factor beta stimulus, P:cellular response to tumor necrosis factor, P:negative regulation of DNA biosynthetic process, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of apoptotic process, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:positive regulation of neuron projection development, P:positive regulation of protein secretion, P:response to muscle stretch, P:sarcomere organization, P:skeletal muscle cell differentiation, P:small molecule metabolic process
UniProtANK repeat, Coiled coil, Complete proteome, Disease mutation, Nucleus, Reference proteome, Repeat
PADBdisease

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)3.8< 0.05RNA microarray18187931
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)4.20cDNA microarray19099603
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.030.005cDNA microarray21411733
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)2.91.99E-44NGS, RNA-seq.22266139
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.271.94E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium