CKDdb-logoCKDdb - Molecule ID A288F

geneALKBH4, ABH4
nameAlkylated DNA repair protein ALKB homolog 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALKB4_HUMANQ9NXW9ENSG0000016099354784Hs.658598613302

Functions and classifications

GOC:contractile ring, C:midbody, C:mitochondrion, C:nucleus, F:actin binding, F:demethylase activity, F:metal ion binding, F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, P:actomyosin structure organization, P:cleavage furrow ingression, P:protein demethylation, P:regulation of transcription, DNA-templated, P:transcription, DNA-templated, C:mitochondrion, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
UniProtAcetylation, Actin-binding, Alternative splicing, Complete proteome, Cytoplasm, Dioxygenase, Iron, Metal-binding, Nucleus, Oxidoreductase, Polymorphism, Reference proteome, Transcription, Transcription regulation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.490.000222RNA microarray19698090
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)4.920.003RNA microarray25770168
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.640.015019RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium