CKDdb-logoCKDdb - Molecule ID A268F

geneAIM2
nameInterferon-inducible protein AIM2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AIM2_HUMANO14862ENSG000001635689447Hs.733411604578

Functions and classifications

GOC:AIM2 inflammasome complex, C:cytosol, C:mitochondrion, C:nucleus, F:double-stranded DNA binding, P:activation of innate immune response, P:apoptotic process, P:cellular response to drug, P:cellular response to interferon-beta, P:inflammatory response, P:innate immune response, P:interleukin-1 beta secretion, P:negative regulation of NF-kappaB transcription factor activity, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:positive regulation of cysteine-type endopeptidase activity, P:positive regulation of defense response to virus by host, P:positive regulation of interleukin-1 beta secretion, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of protein oligomerization, P:pyroptosis, P:tumor necrosis factor-mediated signaling pathway, C:AIM2 inflammasome complex, P:positive regulation of interleukin-1 beta production
UniProt3D-structure, Apoptosis, Complete proteome, Cytoplasm, DNA-binding, Immunity, Inflammatory response, Innate immunity, Nucleus, Polymorphism, Reference proteome, Tumor suppressor
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.120.011271RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium