CKDdb-logoCKDdb - Molecule ID A265F

geneAICDA, AID
nameSingle-stranded DNA cytosine deaminase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AICDA_HUMANQ9GZX7ENSG0000011173257379Hs.149342605257, 605258

Functions and classifications

GOC:cytoplasm, C:nucleus, F:cytidine deaminase activity, F:zinc ion binding, P:B cell differentiation, P:cellular response to lipopolysaccharide, P:DNA demethylation, P:isotype switching, P:mRNA processing, P:negative regulation of methylation-dependent chromatin silencing, P:somatic hypermutation of immunoglobulin genes, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process, F:metal ion binding, P:somatic diversification of immunoglobulins, F:zinc ion binding
UniProtAlternative splicing, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Metal-binding, mRNA processing, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.150.000349RNA microarray19698090
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.233.45E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.120.007928RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium