CKDdb-logoCKDdb - Molecule ID A2620

geneCDKN1C, KIP2
nameCyclin-dependent kinase inhibitor 1C
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CDN1C_HUMANP49918ENSG000001297571028Hs.106070130650, 600856, 614732

Functions and classifications

GOC:cytoplasm, C:nucleus, F:cyclin-dependent protein serine/threonine kinase inhibitor activity, P:cell cycle arrest, P:mitotic G1 phase, P:negative regulation of epithelial cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of transcription, DNA-templated, P:neuron maturation, P:placenta development, P:positive regulation of transcription, DNA-templated, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:regulation of cyclin-dependent protein serine/threonine kinase activity, F:kinase activity, P:negative regulation of protein serine/threonine kinase activity, F:cyclin-dependent protein kinase inhibitor activity, P:G1 phase of mitotic cell cycle, P:negative regulation of transcription, DNA-dependent, P:positive regulation of transcription, DNA-dependent, P:regulation of cyclin-dependent protein kinase activity
UniProtAlternative splicing, Cell cycle, Complete proteome, Disease mutation, Nucleus, Phosphoprotein, Protein kinase inhibitor, Reference proteome, Repeat, Tumor suppressor, Kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16316330dRattus norvegicus10kidneycortexGlomerulonephritis (Thy_1_nephritis)0.23< 0.01cDNA microarray16316330
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.96< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.25< 0.05cDNA microarray17003339
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.490cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.00332RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.090.00328RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.110.00839RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.60.0000366RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.510.000103RNA microarray19698090
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.330.0898RNA microarray20847290
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.440.0369RNA microarray20847290
Exp20926632aRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)0.43< 0.05DNA microarray20926632
Exp20926632bRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)0.44< 0.05DNA microarray20926632
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.02< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.05< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.07< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.12< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.461.45E-21NGS, RNA-seq.22266139
Exp24262798aMus musculus kidneypodocytesnephropathies (collagen IV nephropathies)0.30RNA microarray24262798
Exp24262798bMus musculus kidneypodocytesnephropathies (collagen IV nephropathies)0.290RNA microarray24262798
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.320.00000678RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium