CKDdb-logoCKDdb - Molecule ID A2486

geneSGSH, HSS
nameN-sulphoglucosamine sulphohydrolase precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SPHM_HUMANP51688ENSG000001815236448Hs.31074252900, 605270

Functions and classifications

GOC:lysosomal lumen, F:catalytic activity, F:metal ion binding, F:N-sulfoglucosamine sulfohydrolase activity, F:sulfuric ester hydrolase activity, P:carbohydrate metabolic process, P:glycosaminoglycan catabolic process, P:proteoglycan metabolic process, P:small molecule metabolic process, F:hydrolase activity, P:metabolic process
UniProtCalcium, Complete proteome, Direct protein sequencing, Disease mutation, Glycoprotein, Hydrolase, Lysosome, Metal-binding, Mucopolysaccharidosis, Polymorphism, Reference proteome, Signal
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.018792802LC-MS/MS24172336
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)4.41 +/- 0.23< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)4.51 +/- 0.27< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)5.09 +/- 0.3< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)4.98 +/- 0.28< 0.001RNA microarray24189015

Compile date 08-10-2018© iMODE-CKD consortium