CKDdb-logoCKDdb - Molecule ID A2426

geneARFGEF2, ARFGEP2, BIG2
nameBrefeldin A-inhibited guanine nucleotide-exchange protein 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BIG2_HUMANQ9Y6D5ENSG0000012419810564Hs.62578605371, 608097

Functions and classifications

GOC:asymmetric synapse, C:axonemal microtubule, C:cell junction, C:cytoplasmic membrane-bounded vesicle, C:cytoplasmic vesicle, C:cytosol, C:dendritic spine, C:Golgi membrane, C:microtubule organizing center, C:perinuclear region of cytoplasm, C:recycling endosome, C:symmetric synapse, C:trans-Golgi network, F:ARF guanyl-nucleotide exchange factor activity, F:GABA receptor binding, F:protein kinase A regulatory subunit binding, P:endomembrane system organization, P:endosome organization, P:exocytosis, P:Golgi to plasma membrane transport, P:intracellular signal transduction, P:positive regulation of tumor necrosis factor production, P:protein transport, P:receptor recycling, P:regulation of ARF protein signal transduction, P:regulation of GTPase activity, C:intracellular, C:cytoplasm
UniProt3D-structure, Acetylation, Cell junction, Cell projection, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Disease mutation, Endosome, Golgi apparatus, Guanine-nucleotide releasing factor, Membrane, Phosphoprotein, Polymorphism, Protein transport, Reference proteome, Synapse, Transport
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.150.00000153RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.290.00638RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)0.390.030385505LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium