CKDdb-logoCKDdb - Molecule ID A2425

geneARFGEF1
nameBrefeldin A-inhibited guanine nucleotide-exchange protein 1
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
D3YYK9_MOUSED3YYK9ENSMUSG0000006785110565Mm.229141604141

Functions and classifications

GOC:cytosol, C:Golgi membrane, C:nuclear matrix, C:nucleolus, C:perinuclear region of cytoplasm, C:small nuclear ribonucleoprotein complex, C:trans-Golgi network, F:ARF guanyl-nucleotide exchange factor activity, F:protein kinase A regulatory subunit binding, P:endomembrane system organization, P:exocytosis, P:Golgi organization, P:negative regulation of actin filament polymerization, P:negative regulation of Rho GTPase activity, P:positive regulation of protein glycosylation in Golgi, P:positive regulation of wound healing, P:protein transport, P:regulation of ARF protein signal transduction, P:regulation of establishment of cell polarity, P:regulation of GTPase activity, C:intracellular
UniProt3D-structure, Complete proteome, Cytoplasm, Golgi apparatus, Guanine-nucleotide releasing factor, Membrane, Nucleus, Phosphoprotein, Polymorphism, Protein transport, Reference proteome, Transport
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24172336Mus musculus6kidneycortexAKI (AKI)0.330.014607994LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.54.35E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium