CKDdb-logoCKDdb - Molecule ID A2394

geneArap1, Centd2, Kiaa0782
nameArf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARAP1_MOUSEQ4LDD4ENSMUSG0000003281269710Mm.277687606646

Functions and classifications

GOC:cytoplasmic vesicle, C:Golgi cisterna membrane, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:R-SMAD binding, F:Rho GTPase activator activity, F:sequence-specific DNA binding transcription factor activity, F:transcription factor binding, F:transcription regulatory region DNA binding, F:zinc ion binding, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:positive regulation of transcription, DNA-templated, P:regulation of ARF GTPase activity, P:regulation of cell shape, P:regulation of cellular component movement, P:SMAD protein import into nucleus, P:SMAD protein signal transduction, P:transforming growth factor beta receptor signaling pathway, C:cytoplasmic vesicle, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:Rho GTPase activator activity, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:regulation of cell shape, P:regulation of cellular component movement, P:signal transduction, , C:cytoplasmic vesicle, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:Rho GTPase activator activity, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:regulation of cell shape, P:regulation of cellular component movement, , , C:intracellular, F:GTPase activator activity, P:signal transduction, , C:cytoplasmic vesicle, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:Rho GTPase activator activity, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:regulation of cell shape, P:regulation of cellular component movement, C:cytoplasmic vesicle, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:Rho GTPase activator activity, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:regulation of cell shape, P:regulation of cellular component movement, C:cytoplasmic vesicle, C:plasma membrane, C:trans-Golgi network, F:ARF GTPase activator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:Rho GTPase activator activity, P:negative regulation of stress fiber assembly, P:positive regulation of Cdc42 GTPase activity, P:positive regulation of filopodium assembly, P:positive regulation of receptor recycling, P:regulation of cell shape, P:regulation of cellular component movement
UniProtAlternative splicing, Cell membrane, Complete proteome, Cytoplasm, Golgi apparatus, GTPase activation, Membrane, Metal-binding, Phosphoprotein, Reference proteome, Repeat, Zinc, Zinc-finger
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.420.0000469RNA microarray24569379
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)5.660.003RNA microarray25770168
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)8.410.006241RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium