CKDdb-logoCKDdb - Molecule ID A2381

geneARHGEF17, TEM4
nameRHO guanine nucleotide exchange factor 17
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
ARHGH_HUMANQ96PE2ENSG000001102379828Hs.533719

Functions and classifications

GOC:cytosol, F:guanyl-nucleotide exchange factor activity, F:Rho guanyl-nucleotide exchange factor activity, P:actin cytoskeleton organization, P:apoptotic signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:regulation of Rho GTPase activity, P:small GTPase mediated signal transduction, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction, C:intracellular
UniProtComplete proteome, Guanine-nucleotide releasing factor, Phosphoprotein, Polymorphism, Reference proteome
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.000587RNA microarray19698090
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.470.087RNA microarray20847290
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.250.022973399LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium