CKDdb-logoCKDdb - Molecule ID A2374

geneAbr
nameActive breakpoint cluster region-related protein
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABR_MOUSEQ5SSL4ENSMUSG00000017631109934Mm.258939600365

Functions and classifications

GOC:cytosol, C:plasma membrane, F:GTPase activator activity, F:Rac GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:actin cytoskeleton organization, P:brain development, P:inner ear morphogenesis, P:intracellular signal transduction, P:negative regulation of cell migration, P:negative regulation of inflammatory response, P:negative regulation of neutrophil degranulation, P:neuromuscular process controlling balance, P:positive regulation of GTPase activity, P:positive regulation of phagocytosis, P:positive regulation of Rac GTPase activity, P:response to lipopolysaccharide, F:phospholipid binding
UniProtAlternative splicing, Complete proteome, GTPase activation, Guanine-nucleotide releasing factor, Reference proteome
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis) 2.1< 0.05RNA microarray  18187931
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy) 0.16 LC-MS/MS  19836472
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.35< 0.05RNA microarray  21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI) 1.10.030385505LC-MS/MS  24172336

Compile date 08-30-2016© iMODE-CKD consortium