CKDdb-logoCKDdb - Molecule ID A2344

geneActn4
nameAlpha-actinin-4
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN4_RATQ9QXQ0ENSRNOG0000002043363836Rn.15777603278, 604638

Functions and classifications

GOC:cell-cell junction, C:cortical cytoskeleton, C:cytoplasm, C:cytosol, C:extracellular vesicular exosome, C:neuron projection, C:nucleus, C:perinuclear region of cytoplasm, C:protein complex, C:pseudopodium, C:ribonucleoprotein complex, C:stress fiber, C:Z disc, F:calcium ion binding, F:nucleoside binding, F:protein binding, F:protein complex binding, F:protein N-terminus binding, P:actin filament bundle assembly, P:negative regulation of cellular component movement, P:positive regulation of cellular component movement, P:positive regulation of pinocytosis, P:protein transport, P:regulation of apoptotic process, P:response to hypoxia, P:tight junction assembly, P:actin crosslink formation, F:calcium ion binding, P:actin crosslink formation, P:actin filament bundle assembly, F:calcium ion binding, P:actin crosslink formation, P:actin filament bundle assembly
UniProtAcetylation, Actin-binding, Calcium, Cell junction, Complete proteome, Cytoplasm, Metal-binding, Nucleus, Protein transport, Reference proteome, Repeat, Transport, ,
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.22< 0.05cDNA microarray 17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.6< 0.05cDNA microarrayRT-PCR17003339
Exp19136817Mus musculus10kidneyglomeruliUrination_Disorders (proteinuria)0.640.00303RNA microarray 19136817
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS 20543976
Exp20716515Homo sapiens kidneyproximal tubule epithelial cellFibrosis (TGFbeta in vitro model)1.270.042MALDI-TOF 20716515
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.32< 0.05LC-MS/MS 20940332
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.22< 0.05RNA microarray 21752957
Exp22007191Rattus norvegicus20kidneyglomeruliDiabetes (Diabetic Nephropathy)1.22< 0.0001LC-ESI-MS/MS 22007191
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)0.810.0001QSTAR Elite LC-MS/MS 22172726
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.350.00372RNA microarray 23291264
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)0.790.01507627LC-MS/MS 24316357
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy)3.4< 0.05MALDI-TOF/TOFWestern blotting, RT-PCR, immunohistochemistry24434790
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy)3.79< 0.05MALDI-TOF/TOFWestern blotting, RT-PCR, immunohistochemistry24434790

Compile date 08-10-2018© iMODE-CKD consortium