CKDdb-logoCKDdb - Molecule ID A2341

geneACTN1
nameAlpha-actinin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN1_HUMANP12814ENSG0000007211087Hs.509765102575, 615193

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:dendritic spine, C:extracellular vesicular exosome, C:fascia adherens, C:focal adhesion, C:nucleus, C:plasma membrane, C:platelet alpha granule lumen, C:pseudopodium, C:ruffle, C:Z disc, F:calcium ion binding, F:double-stranded RNA binding, F:integrin binding, P:actin filament bundle assembly, P:extracellular matrix organization, P:focal adhesion assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:regulation of apoptotic process, C:cortical actin cytoskeleton, C:stress fiber, P:actin crosslink formation
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell junction, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.320.04cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.281.08E-08RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.293.88E-09RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.350.00000136RNA microarray19698090
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.386.90E-07RNA microarray20813037
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.32< 0.05LC-MS/MS20940332
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)10.42< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.81< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.84< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.11< 0.05RNA microarray21752957
Exp22007191Rattus norvegicus20kidneyglomeruliDiabetes (Diabetic Nephropathy)1.4< 0.0001LC-ESI-MS/MS22007191
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.280.000000433mRNA microarray23326503
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.49 nLC-ESI-UHR-QToF-MS/MS23344851
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)3.040.000074RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium