CKDdb-logoCKDdb - Molecule ID A2257

geneANGPT1, AngA
nameAngiopoietin-1 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANGP1_HUMANQ15389ENSG00000154188284Hs.369675601667

Functions and classifications

GOC:extracellular space, C:membrane raft, C:microvillus, C:plasma membrane, P:activation of transmembrane receptor protein tyrosine kinase activity, P:blood coagulation, P:cell differentiation, P:cell-substrate adhesion, P:glomerulus vasculature development, P:hemopoiesis, P:heparin biosynthetic process, P:in utero embryonic development, P:leukocyte migration, P:negative regulation of cell adhesion, P:negative regulation of endothelial cell apoptotic process, P:negative regulation of neuron apoptotic process, P:negative regulation of vascular permeability, P:positive chemotaxis, P:positive regulation of blood vessel endothelial cell migration, P:positive regulation of cell adhesion, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of phosphatidylinositol 3-kinase signaling, P:positive regulation of protein kinase B signaling, P:positive regulation of protein ubiquitination, P:positive regulation of receptor internalization, P:protein localization to cell surface, P:regulation of satellite cell proliferation, P:sprouting angiogenesis, P:Tie signaling pathway, P:angiogenesis, P:transmembrane receptor protein tyrosine kinase signaling pathway, P:organ regeneration, P:ovarian follicle development, P:positive regulation of phosphatidylinositol 3-kinase cascade, P:positive regulation of protein kinase B signaling cascade, P:protein homooligomerization, P:response to estrogen stimulus, P:response to hypoxia, P:response to vitamin B3, P:Tie receptor signaling pathway, P:signal transduction
UniProt3D-structure, Alternative splicing, Angiogenesis, Coiled coil, Complete proteome, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.0114RNA microarray19698090
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.31.47E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium