CKDdb-logoCKDdb - Molecule ID A2256

geneANGPT2, angiopoietin-2B, AGPT2
nameAngiopoietin-2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANGP2_HUMANO15123ENSG00000091879285Hs.583870601922

Functions and classifications

GOC:cell projection, C:extracellular space, C:nucleus, C:plasma membrane, F:metal ion binding, F:receptor binding, P:angiogenesis, P:blood coagulation, P:cellular response to growth factor stimulus, P:germ cell development, P:glomerulus vasculature development, P:leukocyte migration, P:maternal process involved in female pregnancy, P:negative regulation of angiogenesis, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cell-substrate adhesion, P:negative regulation of positive chemotaxis, P:organ regeneration, P:positive regulation of angiogenesis, P:response to activity, P:response to glucose, P:response to hypoxia, P:response to mechanical stimulus, P:response to organic cyclic compound, P:response to radiation, P:Tie signaling pathway, P:response to glucose stimulus, P:Tie receptor signaling pathway, P:signal transduction
UniProt3D-structure, Alternative splicing, Angiogenesis, Calcium, Coiled coil, Complete proteome, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Metal-binding, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19136817Mus musculus10kidneyglomeruliUrination_Disorders (proteinuria)1.990.003RNA microarray19136817
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.20.000832RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.0335RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.687.68E-08RNA microarray24569379
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.140.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium