CKDdb-logoCKDdb - Molecule ID A2222

geneBRD4, HUNK1
nameBromodomain-containing protein 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BRD4_HUMANO60885ENSG0000014186723476Hs.187763608749

Functions and classifications

GOC:chromosome, C:condensed nuclear chromosome, C:cytoplasm, C:nuclear chromatin, F:chromatin binding, F:DNA binding, F:histone acetyl-lysine binding, F:p53 binding, P:cellular response to DNA damage stimulus, P:chromatin remodeling, P:chromosome segregation, P:histone H3-K14 acetylation, P:histone H4-K12 acetylation, P:inner cell mass cell proliferation, P:negative regulation of DNA damage checkpoint, P:positive regulation of DNA binding, P:positive regulation of G2/M transition of mitotic cell cycle, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of transcription elongation from RNA polymerase II promoter, P:positive regulation of transcription from RNA polymerase II promoter, P:protein phosphorylation, P:regulation of inflammatory response, P:regulation of phosphorylation of RNA polymerase II C-terminal domain, P:regulation of transcription involved in G1/S transition of mitotic cell cycle, P:transcription, DNA-templated, P:viral process, P:regulation of transcription involved in G1 phase of mitotic cell cycle, P:virus-host interaction
UniProt3D-structure, Acetylation, Alternative splicing, Bromodomain, Chromatin regulator, Chromosomal rearrangement, Chromosome, Complete proteome, DNA damage, Host-virus interaction, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transcription, Transcription regulation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0000376RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.000563RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium