CKDdb-logoCKDdb - Molecule ID A208A

geneAFF2, FMR2, OX19
nameFragile X mental retardation 2 protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AFF2_HUMANP51816ENSG000001559662334Hs.496911300806, 309548

Functions and classifications

GOC:nuclear speck, F:G-quadruplex RNA binding, P:brain development, P:learning or memory, P:mRNA processing, P:regulation of RNA splicing, P:RNA splicing
UniProtAlternative splicing, Complete proteome, Mental retardation, mRNA processing, mRNA splicing, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, RNA-binding, Triplet repeat expansion
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.070.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.470.0060895RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.240.000258RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.380.00311RNA microarray19698090
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.350.0155888RNA microarray23935909
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.331.41E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium