CKDdb-logoCKDdb - Molecule ID A2081

geneAPAF1
nameApoptotic protease activating factor 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APAF_HUMANO14727ENSG00000120868317Hs.552567602233

Functions and classifications

GOC:apoptosome, C:Golgi apparatus, C:nucleus, F:ADP binding, F:ATP binding, F:cysteine-type endopeptidase activator activity involved in apoptotic process, F:nucleotide binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, P:apoptotic DNA fragmentation, P:defense response, P:forebrain development, P:intrinsic apoptotic signaling pathway, P:nervous system development, P:neural tube closure, P:neuron apoptotic process, P:positive regulation of apoptotic process, P:positive regulation of apoptotic signaling pathway, P:response to G1 DNA damage checkpoint signaling, C:intracellular, P:regulation of apoptotic process
UniProt3D-structure, Alternative splicing, Apoptosis, ATP-binding, Calcium, Complete proteome, Cytoplasm, Direct protein sequencing, Nucleotide-binding, Reference proteome, Repeat, WD repeat
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666aMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)0.440.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.0106RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.460.00071RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.81< 0.05RNA microarray21752957
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)4.440.0017202RNA microarray23935909
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.450.00000208RNA microarray24569379
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.140.004374RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium