CKDdb-logoCKDdb - Molecule ID A2062

geneAtrx
nameTranscriptional regulator ATRX
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATRX_MOUSEQ61687ENSMUSG0000003122922589Mm.10141300032, 300448, 301040, 309580, 309590, 309470

Functions and classifications

GOC:heterochromatin, C:nuclear chromosome, C:nucleus, C:PML body, C:SWI/SNF superfamily-type complex, C:telomeric heterochromatin, F:ATP binding, F:chromatin binding, F:DNA binding, F:helicase activity, F:histone binding, F:protein binding, F:zinc ion binding, P:cellular response to hydroxyurea, P:chromatin remodeling, P:DNA damage response, signal transduction by p53 class mediator, P:DNA repair, P:DNA replication-independent nucleosome assembly, P:forebrain development, P:negative regulation of telomeric RNA transcription from RNA pol II promoter, P:nucleosome assembly, P:positive regulation of nuclear cell cycle DNA replication, P:positive regulation of telomere maintenance, P:positive regulation of transcription from RNA polymerase II promoter, P:replication fork processing, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, P:transcription, DNA-templated, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, F:zinc ion binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, F:zinc ion binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, F:zinc ion binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, F:zinc ion binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis, C:heterochromatin, C:nuclear chromosome, C:nucleus, F:chromatin binding, F:protein binding, F:zinc ion binding, P:forebrain development, P:positive regulation of transcription from RNA polymerase II promoter, P:seminiferous tubule development, P:Sertoli cell development, P:spermatogenesis
UniProtATP-binding, Chromatin regulator, Chromosome, Citrullination, Complete proteome, DNA damage, DNA repair, DNA-binding, Helicase, Hydrolase, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Telomere, Transcription, Transcription regulation, Zinc, Zinc-finger, Complete proteome, Reference proteome, Complete proteome, Reference proteome, Complete proteome, Reference proteome, Complete proteome, Reference proteome, Complete proteome, Reference proteome, , , , , Complete proteome, Reference proteome, Complete proteome, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)0.81< 0.05LC-MS/MS20940332
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.860.047822241LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.331.97E-05RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.330.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium