CKDdb-logoCKDdb - Molecule ID A204F

geneAPOBEC1
nameApolipoprotein B mRNA editing enzyme
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABEC1_HUMANP41238ENSG00000111701339Hs.560600130

Functions and classifications

GOC:cytoplasm, C:nucleoplasm, F:AU-rich element binding, F:cytidine deaminase activity, F:RNA binding, F:zinc ion binding, P:cellular response to insulin stimulus, P:cytidine to uridine editing, P:defense response to virus, P:DNA demethylation, P:lipid metabolic process, P:lipoprotein biosynthetic process, P:lipoprotein transport, P:mRNA modification, P:mRNA processing, P:mRNA stabilization, P:negative regulation of methylation-dependent chromatin silencing, P:regulation of cell proliferation, P:response to calcium ion, P:response to drug, P:response to ethanol, P:response to gamma radiation, P:response to osmotic stress, P:response to zinc ion, P:RNA processing, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process, F:metal ion binding, F:zinc ion binding
UniProtComplete proteome, Cytoplasm, Hydrolase, Metal-binding, mRNA processing, Polymorphism, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.210.0000141RNA microarray19698090
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.22.19E-08RNA microarray20813037
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.318.26E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium