CKDdb-logoCKDdb - Molecule ID A2011

geneCASP9, MCH6, CASPASE-9c
nameCaspase-9 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP9_HUMANP55211ENSP00000330237842Hs.329502602234

Functions and classifications

GOC:apoptosome, C:mitochondrion, C:nucleus, F:cysteine-type endopeptidase activity, F:enzyme activator activity, F:protein kinase binding, F:SH3 domain binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, P:aging, P:cellular response to dexamethasone stimulus, P:cellular response to UV, P:epidermal growth factor receptor signaling pathway, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:glial cell apoptotic process, P:innate immune response, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:neurotrophin TRK receptor signaling pathway, P:phosphatidylinositol-mediated signaling, P:platelet formation, P:positive regulation of apoptotic process, P:positive regulation of neuron apoptotic process, P:proteolysis, P:regulation of response to DNA damage stimulus, P:response to antibiotic, P:response to cobalt ion, P:response to estradiol, P:response to lipopolysaccharide, P:signal transduction in response to DNA damage, C:intracellular, P:apoptotic process, P:regulation of apoptotic process, C:cytosol, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:cellular response to DNA damage stimulus, P:response to UV, P:nerve growth factor receptor signaling pathway, P:response to DNA damage stimulus
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Hydrolase, Phosphoprotein, Polymorphism, Protease, Reference proteome, Thiol protease, Zymogen
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.32< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium