CKDdb-logoCKDdb - Molecule ID A2007

geneHSPA1A, HSPA1B, HSPA1
nameHeat shock 70 kDa protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
HSP71_HUMANP08107ENSG000002043883303Hs.274402140550, 603012

Functions and classifications

GOC:aggresome, C:cytosol, C:endoplasmic reticulum, C:mitochondrion, C:nuclear speck, C:perinuclear region of cytoplasm, C:ribonucleoprotein complex, F:ATP binding, F:double-stranded RNA binding, F:protein binding involved in protein folding, F:unfolded protein binding, F:virus receptor activity, P:gene expression, P:mRNA catabolic process, P:negative regulation of apoptotic process, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:negative regulation of inclusion body assembly, P:positive regulation of erythrocyte differentiation, P:protein refolding, P:response to unfolded protein, P:response to virus, P:response to stress
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Chaperone, Complete proteome, Cytoplasm, Direct protein sequencing, Host cell receptor for virus entry, Methylation, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Stress response
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)27.858 +/- 1.072< 0.05RNA microarray 18354378
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)29.243 +/- 1.079< 0.05RNA microarray 18354378
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.00266RNA microarray 19698090
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS 20543976
Exp21595033bHomo sapiens14urineexosomesGlomerulonephritis (basement membrane nephropathy)0.470.0309LC-MS/MS 21595033
Exp23078846Homo sapiens12kidneyperitoneal dialysateDialysis (Peritonitis)down< 0.05RP-nano-HPLC-ESI-MS/MSwestern blot, ELISA23078846
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)0.320.007RNA microarray 23760282
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.52< 0.05LC-MS/MS 24497609
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)12.262.05E-04RNA microarray 26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)8.341.92E-04RNA microarray 26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)12.650.008306RNA microarray 26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)21.340.004091RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium