CKDdb-logoCKDdb - Molecule ID A193F

geneAdora2a
nameAdenosine receptor A2a
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AA2AR_MOUSEQ60613ENSMUSG0000002017811540Mm.333734102776

Functions and classifications

GOC:asymmetric synapse, C:axolemma, C:dendrite, C:endomembrane system, C:integral component of plasma membrane, C:membrane, C:neuronal cell body, C:plasma membrane, C:postsynaptic density, C:postsynaptic membrane, C:presynaptic active zone, C:presynaptic membrane, F:G-protein coupled adenosine receptor activity, P:adenosine receptor signaling pathway, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:astrocyte activation, P:eating behavior, P:G-protein coupled receptor signaling pathway, P:locomotory behavior, P:negative regulation of alpha-beta T cell activation, P:negative regulation of cell proliferation, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of inflammatory response, P:negative regulation of locomotion, P:negative regulation of neuron apoptotic process, P:negative regulation of protein kinase activity, P:negative regulation of vascular permeability, P:neuron projection morphogenesis, P:positive regulation of acetylcholine secretion, neurotransmission, P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway, P:positive regulation of apoptotic signaling pathway, P:positive regulation of cAMP biosynthetic process, P:positive regulation of circadian sleep/wake cycle, sleep, P:positive regulation of glutamate secretion, P:positive regulation of protein secretion, P:positive regulation of renal sodium excretion, P:positive regulation of synaptic transmission, GABAergic, P:positive regulation of synaptic transmission, glutamatergic, P:positive regulation of urine volume, P:prepulse inhibition, P:protein kinase C-activating G-protein coupled receptor signaling pathway, P:regulation of calcium ion transport, P:regulation of excitatory postsynaptic membrane potential, P:regulation of inhibitory postsynaptic membrane potential, P:regulation of mitochondrial membrane potential, P:regulation of norepinephrine secretion, P:regulation of synaptic plasticity, P:regulation of transcription, DNA-templated, P:response to amphetamine, P:response to caffeine, P:response to drug, P:synaptic transmission, cholinergic, P:synaptic transmission, dopaminergic, P:synaptic transmission, glutamatergic, P:vasodilation, C:Golgi membrane, C:integral to membrane, C:intermediate filament, P:positive regulation of acetylcholine secretion, P:regulation of transcription, DNA-dependent, C:integral component of membrane
UniProtCell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix, Ubl conjugation
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.433.23E-06RNA microarray20019191
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.410.003cDNA microarray21411733

Compile date 08-10-2018© iMODE-CKD consortium