CKDdb-logoCKDdb - Molecule ID A1877

geneABCC8, SUR1, SUR
nameSulfonylurea receptor 1
speciesHomo sapiens

Molecule reference

ABCC8_HUMANQ09428ENSG000000060716833Hs.54470240800, 256450, 600509, 602485, 606176, 610374

Functions and classifications

GOC:voltage-gated potassium channel complex, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:potassium ion transmembrane transporter activity, F:sulfonylurea receptor activity, P:ATP catabolic process, P:carbohydrate metabolic process, P:energy reserve metabolic process, P:regulation of insulin secretion, P:synaptic transmission, C:integral component of membrane, P:potassium ion transport, P:signal transduction, P:ATP catabolic process, C:sarcolemma, C:synaptic vesicle membrane, C:voltage-gated potassium channel complex, F:potassium channel activity, P:negative regulation of insulin secretion, P:positive regulation of potassium ion transport, P:response to drug, P:response to insulin stimulus, P:response to lipopolysaccharide, P:response to pH, P:response to zinc ion, C:integral to membrane, P:potassium ion transport, F:ATPase activity, coupled to transmembrane movement of substances
UniProtAlternative splicing, ATP-binding, Complete proteome, Diabetes mellitus, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Polymorphism, Receptor, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.360.000455RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.430.0158RNA microarray  19698090
Exp20926632aRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease) 0.45< 0.05DNA microarray  20926632
Exp20926632bRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease) 0.44< 0.05DNA microarray  20926632
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 0.38< 0.05RNA-seq  23757392

Compile date 08-30-2016© iMODE-CKD consortium