CKDdb-logoCKDdb - Molecule ID A184C

geneSLC8A1, ncx1, CNC
nameSodium/calcium exchanger 1 precursor
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:basolateral plasma membrane, C:integral component of plasma membrane, C:intercalated disc, C:T-tubule, C:Z disc, F:ankyrin binding, F:calcium:sodium antiporter activity, F:ion channel binding, F:metal ion binding, P:blood coagulation, P:calcium ion export, P:calcium ion import, P:calcium ion transport into cytosol, P:cardiac muscle cell development, P:cardiac muscle contraction, P:cell communication by electrical coupling involved in cardiac conduction, P:cellular response to caffeine, P:cellular response to reactive oxygen species, P:embryonic heart tube development, P:embryonic placenta development, P:heart morphogenesis, P:muscle fiber development, P:negative regulation of cytosolic calcium ion concentration, P:post-embryonic development, P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, P:regulation of heart rate, P:regulation of the force of heart contraction, P:relaxation of cardiac muscle, P:relaxation of smooth muscle, P:sodium ion export, P:sodium ion import, P:vascular smooth muscle contraction, C:membrane, P:calcium ion transmembrane transport, P:sodium ion transmembrane transport, C:integral component of membrane, P:cell communication, C:dendritic spine, C:integral to plasma membrane, C:microtubule, C:mitochondrion, P:cellular response to cAMP, P:reduction of cytosolic calcium ion concentration, P:regulation of sodium ion transport, P:response to ATP, P:response to drug, P:response to glucose stimulus, P:response to hydrogen peroxide, P:response to hypoxia, P:response to nutrient, P:telencephalon development, C:integral to membrane, P:regulation of calcium ion transport
UniProtAlternative splicing, Antiport, Calcium, Calcium transport, Calmodulin-binding, Cell membrane, Complete proteome, Glycoprotein, Ion transport, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Signal, Sodium, Sodium transport, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)4.48< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)7.89< 0.05cDNA microarray17003339
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.00536RNA microarray19698090
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)1.950.0797RNA microarray20847290
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)5.780.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium