CKDdb-logoCKDdb - Molecule ID A1846

geneADAM10, KUZ, MADM
nameADAM 10 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA10_HUMANO14672ENSP00000260408102Hs.578508602192

Functions and classifications

GOC:cell surface, C:endomembrane system, C:Golgi-associated vesicle, C:integral component of membrane, C:nucleus, C:plasma membrane, C:postsynaptic density, F:integrin binding, F:metalloendopeptidase activity, F:protein homodimerization activity, F:protein kinase binding, F:zinc ion binding, P:cell-cell signaling, P:collagen catabolic process, P:constitutive protein ectodomain proteolysis, P:epidermal growth factor receptor signaling pathway, P:extracellular matrix disassembly, P:in utero embryonic development, P:integrin-mediated signaling pathway, P:monocyte activation, P:negative regulation of cell adhesion, P:Notch receptor processing, P:Notch signaling pathway, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of T cell chemotaxis, P:protein phosphorylation, P:response to tumor necrosis factor, F:metallopeptidase activity, P:metabolic process, P:proteolysis, C:extracellular region, P:membrane protein ectodomain proteolysis, C:integral to membrane, F:metal ion binding
UniProt3D-structure, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Polymorphism, Protease, Reference proteome, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen, Integrin
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.320.026MALDI-TOF/TOF21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.96< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.2< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.87< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.285.83E-08RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium