CKDdb-logoCKDdb - Molecule ID A1818

geneAbcb2, Mtp1
nameAntigen peptide transporter 1
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TAP1_RATP36370ENSRNOG0000000045724811Rn.10763170260, 604571

Functions and classifications

GOC:intracellular membrane-bounded organelle, C:plasma membrane, C:TAP complex, F:ADP binding, F:ATP binding, F:ATPase activity, F:MHC class I protein binding, F:nucleotide binding, F:oligopeptide-transporting ATPase activity, F:peptide antigen-transporting ATPase activity, F:protein heterodimerization activity, F:protein homodimerization activity, F:TAP1 binding, F:TAP2 binding, F:tapasin binding, P:ATP catabolic process, P:oligopeptide transmembrane transport, P:peptide antigen transport, P:peptide transport, P:positive regulation of T cell mediated cytotoxicity, P:protection from natural killer cell mediated cytotoxicity, P:protein transport, P:transmembrane transport, C:mitochondrion, P:antigen processing and presentation of endogenous peptide antigen via MHC class I, P:cytosol to ER transport, P:defense response, P:intracellular transport of viral proteins in host cell, C:integral component of endoplasmic reticulum membrane, C:mitochondrion, F:ADP binding, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:peptide transporter activity, P:antigen processing and presentation of endogenous peptide antigen via MHC class I, P:cytosol to ER transport, P:defense response, P:intracellular transport of viral protein in host cell, C:integral to endoplasmic reticulum membrane, P:ATP catabolic process, P:intracellular transport of viral proteins in host cell, C:integral component of membrane, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:peptide transporter activity, C:integral to membrane, P:ATP catabolic process, C:integral component of membrane, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:peptide transporter activity, C:integral to membrane, P:ATP catabolic process, C:integral component of membrane, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:peptide transporter activity, C:integral to membrane, P:ATP catabolic process
UniProt3D-structure, Adaptive immunity, ATP-binding, Complete proteome, Endoplasmic reticulum, Immunity, Membrane, Nucleotide-binding, Peptide transport, Protein transport, Reference proteome, Transmembrane, Transmembrane helix, Transport, ATP-binding, Complete proteome, Nucleotide-binding, Reference proteome, ATP-binding, Nucleotide-binding, ,
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis) 6.4< 0.05RNA microarray  18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis) 2.4< 0.05RNA microarray  18187931
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 3.073.23E-06RNA microarray  20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 3.85< 0.05RNA microarray  21752957
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 3.660.000572RNA microarray  23291264

Compile date 08-30-2016© iMODE-CKD consortium