CKDdb-logoCKDdb - Molecule ID A1809

geneAPOC2, APC2
nameApolipoprotein C-II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC2_HUMANP02655ENSG00000234906344Hs.75615207750, 608083

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:lipase inhibitor activity, F:lipid binding, F:lipoprotein lipase activator activity, F:phospholipase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:chylomicron remnant clearance, P:chylomicron remodeling, P:high-density lipoprotein particle clearance, P:lipid catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol transport, P:negative regulation of lipid metabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of phospholipase activity, P:positive regulation of phospholipid catabolic process, P:positive regulation of triglyceride catabolic process, P:positive regulation of very-low-density lipoprotein particle remodeling, P:response to drug, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride homeostasis, P:very-low-density lipoprotein particle remodeling, F:enzyme activator activity, P:lipid metabolic process, P:lipid transport, P:positive regulation of catalytic activity
UniProt3D-structure, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Hyperlipidemia, Lipid degradation, Lipid metabolism, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.9188nanoLC-ESI-MS/MS17301227
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)12.3< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)3.9< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.00219RNA microarray19698090
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)0.10.2124LC-MS/MS20812764
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)0.365.57E-07RNA microarray20813037
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)3.190cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.380.007cDNA microarray21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.31< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.4< 0.05RNA-seq23757392
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)2.670.0421774RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium