CKDdb-logoCKDdb - Molecule ID A1805

geneACE, DCP, DCP1
nameAngiotensin-converting enzyme
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACE_HUMANP12821ENSG000001596401636Hs.298469106180, 267430, 601367, 612624, 614519

Functions and classifications

GOC:endosome, C:external side of plasma membrane, C:extracellular space, C:integral component of membrane, C:plasma membrane, F:actin binding, F:carboxypeptidase activity, F:chloride ion binding, F:drug binding, F:endopeptidase activity, F:metallopeptidase activity, F:peptidyl-dipeptidase activity, F:zinc ion binding, P:angiotensin catabolic process in blood, P:angiotensin maturation, P:arachidonic acid secretion, P:blood vessel remodeling, P:cellular protein metabolic process, P:hematopoietic stem cell differentiation, P:hormone catabolic process, P:kidney development, P:mononuclear cell proliferation, P:peptide catabolic process, P:proteolysis, P:regulation of renal output by angiotensin, P:regulation of smooth muscle cell migration, P:regulation of vasoconstriction, P:regulation of vasodilation, C:membrane, C:integral to membrane, F:metal ion binding
UniProt3D-structure, Alternative splicing, Carboxypeptidase, Cell membrane, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Phosphoprotein, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Signal, Transmembrane, Transmembrane helix, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.340.01cDNA microarray  19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.450.01cDNA microarray  19099603
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection) 0.2 LC-MS/MS  20543976
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy) 0.350.04362511NGS, RNA-seq.  22266139
Exp24172336Mus musculus6kidneycortexAKI (AKI) 2.440.005325151LC-MS/MS  24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.353.55E-03RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium