CKDdb-logoCKDdb - Molecule ID A1804

geneREN
nameRenin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
RENI_HUMANP00797ENSG000001438395972Hs.3210179820, 267430, 613092

Functions and classifications

GOC:extracellular space, C:intracellular, C:plasma membrane, F:aspartic-type endopeptidase activity, P:angiotensin maturation, P:beta-amyloid metabolic process, P:cell maturation, P:cellular protein metabolic process, P:cellular response to drug, P:drinking behavior, P:hormone-mediated signaling pathway, P:kidney development, P:male gonad development, P:mesonephros development, P:proteolysis, P:regulation of MAPK cascade, P:renin-angiotensin regulation of aldosterone production, P:response to cAMP, P:response to cGMP, P:response to lipopolysaccharide, F:endopeptidase activity, C:cytoplasmic part, C:membrane, P:response to drug, P:response to stress
UniProt3D-structure, Alternative splicing, Aspartyl protease, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Polymorphism, Protease, Reference proteome, Secreted, Signal, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.93< 0.05cDNA microarray 17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.47< 0.05cDNA microarray 17003339
Exp17579666bMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.030.05RNA microarraysqRT-PCR17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.440.02cDNA microarray 19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.170.000012RNA microarray 19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.510.003379912LC-MS/MS 24172336
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)1.07< 0.05LC-MS/MS 24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)1.67< 0.05LC-MS/MS 24927646
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)10.061.00E-03RNA microarray 26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)28.010.006367RNA microarray 26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.950.013999RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium