CKDdb-logoCKDdb - Molecule ID A1760

geneAML2, RUNX3, CBFA3
nameRUNT-related transcription factor 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
RUNX3_HUMANQ13761ENSG00000020633864Hs.170019600210

Functions and classifications

GOC:cytoplasm, C:nuclear chromatin, F:ATP binding, F:RNA polymerase II regulatory region sequence-specific DNA binding, F:sequence-specific DNA binding RNA polymerase II transcription factor activity, P:axon guidance, P:cell maturation, P:chondrocyte differentiation, P:hair follicle morphogenesis, P:interferon-gamma production, P:negative regulation of cell cycle, P:negative regulation of epithelial cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:peripheral nervous system neuron development, P:positive regulation of extrinsic apoptotic signaling pathway, P:protein phosphorylation, C:nucleus, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:transcription, DNA-templated, P:regulation of transcription, DNA-templated, P:induction of apoptosis, C:nucleus, P:regulation of transcription, DNA-dependent
UniProtAlternative splicing, Complete proteome, Cytoplasm, DNA-binding, Nucleus, Phosphoprotein, Reference proteome, Transcription, Transcription regulation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)4.469 +/- 1.102< 0.05RNA microarray18354378
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.33< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.53< 0.05RNA microarray21752957
Exp23809614aHomo sapiens83bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)5.623.61E-15RNA microarray23809614
Exp23809614bHomo sapiens32bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)5.431.30E-12RNA microarray23809614
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.650.007925585LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium