CKDdb-logoCKDdb - Molecule ID A1736

geneC5AR1, C5AR, C5R1
nameC5a anaphylatoxin chemotactic receptor 1
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:apical part of cell, C:basolateral plasma membrane, C:cell surface, C:integral component of plasma membrane, F:C5a anaphylatoxin receptor activity, F:complement component C5a receptor activity, F:N-formyl peptide receptor activity, P:activation of MAPK activity, P:activation of phospholipase C activity, P:apoptotic process, P:cell proliferation in hindbrain, P:cellular defense response, P:chemotaxis, P:defense response to Gram-positive bacterium, P:immune response, P:inflammatory response, P:mRNA transcription from RNA polymerase II promoter, P:negative regulation of neuron apoptotic process, P:neutrophil chemotaxis, P:organ regeneration, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of epithelial cell proliferation, P:positive regulation of ERK1 and ERK2 cascade, P:response to lipopolysaccharide, P:response to peptidoglycan, P:sensory perception of chemical stimulus, C:integral to plasma membrane, P:elevation of cytosolic calcium ion concentration
UniProtCell membrane, Chemotaxis, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Sulfation, Transducer, Transmembrane, Transmembrane helix

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.189.36E-18NGS, RNA-seq.22266139
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1)))2.110.0108RNA microarray25133636

Compile date 08-10-2018© iMODE-CKD consortium