CKDdb-logoCKDdb - Molecule ID A1714

geneApob
nameApolipoprotein B-100
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOB_MOUSEE9Q414ENSMUSG00000020609238055Mm.221239107730, 144010, 615558

Functions and classifications

GOC:endoplasmic reticulum, C:extracellular region, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:mature chylomicron, C:very-low-density lipoprotein particle, C:vesicle lumen, C:vesicle membrane, F:cholesterol transporter activity, F:heparin binding, F:phospholipid binding, P:artery morphogenesis, P:cellular response to prostaglandin stimulus, P:cellular response to tumor necrosis factor, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:cholesterol transport, P:fertilization, P:in utero embryonic development, P:lipid catabolic process, P:lipid metabolic process, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:low-density lipoprotein particle clearance, P:low-density lipoprotein particle remodeling, P:nervous system development, P:positive regulation of cholesterol storage, P:positive regulation of macrophage derived foam cell differentiation, P:post-embryonic development, P:regulation of cholesterol biosynthetic process, P:response to carbohydrate, P:response to lipopolysaccharide, P:response to selenium ion, P:response to virus, P:sperm motility, P:spermatogenesis, P:triglyceride catabolic process, P:triglyceride mobilization, C:endoplasmic reticulum, F:lipid transporter activity, P:artery morphogenesis, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol transport, P:fertilization, P:in utero embryonic development, P:lipid catabolic process, P:lipid metabolic process, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:nervous system development, P:post-embryonic development, P:regulation of cholesterol biosynthetic process, P:sperm motility, P:spermatogenesis, P:triglyceride catabolic process, P:triglyceride mobilization, C:endoplasmic reticulum, P:artery morphogenesis, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol transport, P:fertilization, P:in utero embryonic development, P:lipid catabolic process, P:lipid metabolic process, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:nervous system development, P:post-embryonic development, P:regulation of cholesterol biosynthetic process, P:sperm motility, P:spermatogenesis, P:triglyceride catabolic process, P:triglyceride mobilization
UniProtAcetylation, Cholesterol metabolism, Chylomicron, Coiled coil, Complete proteome, Cytoplasm, Disulfide bond, Glycoprotein, Heparin-binding, LDL, Lipid metabolism, Lipid transport, Lipoprotein, Palmitate, Reference proteome, Repeat, RNA editing, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport, VLDL
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19688726aRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)2.3 MALDI-TOF19688726
Exp19688726bRattus norvegicus kidneyinterstitial fibroblastFibrosis (TGFbeta in vitro model)0.03 MALDI-TOF19688726
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)0.250.0001LC-MS/MS20812764
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)3.340.00003LC-MS/MS23228063
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.220.0000895RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium